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Tirzepatide Plus is a customized treatment created for Willow patients who require a more tailored approach to GLP-1/GIP therapy. Designed for those whose health profiles or goals require clinical personalization, this compounded formulation is developed in collaboration with your Willow physician as part of your individualized care plan.
At its core is Tirzepatide, a next-generation dual agonist that targets both GLP-1 and GIP receptors to help regulate appetite, support metabolic balance, and drive meaningful weight loss. To match your unique physiology and treatment goals, your formulation may also include supportive ingredients like Cyanocobalamin (Vitamin B12) to boost energy, or L-Carnitine to aid fat metabolism and muscle preservation.
Every dose is compounded with your specific needs in mind—offering a personalized path to sustainable weight loss and overall well-being. This isn’t a standard treatment; it’s one made just for you.
Because your journey is personal—and your medication should be too.
Semaglutide and tirzepatide are both medications used for weight loss, but they have distinct differences.
Semaglutide is a GLP-1 receptor agonist, which helps to regulate blood sugar by enhancing insulin secretion, slowing gastric emptying, and promoting satiety.
Tirzepatide, on the other hand, is a dual agonist, targeting both the GLP-1 and GIP receptors, offering enhanced glucose control and weight loss by combining the effects of both incretin hormones. Clinical trials suggest that tirzepatide offers superior efficacy in both glucose lowering and weight reduction compared to semaglutide.
When you eat, the food stimulates your gut to release the GLP-1 hormone. GLP-1 helps lower blood glucose (blood sugar) by triggering insulin release. Insulin helps blood glucose enter your body’s cells for later energy use.
In some people, the gut doesn't make enough natural GLP-1, or the brain isn't sensitive to it.
Tirzepatide is a synthetic GLP-1 RA (receptor agonist). A drug that works as an agonist activates the same cell receptors as the body’s natural hormones. Semaglutide works in the gut like the body’s natural GLP-1, slowing digestion, curbing hunger, and signaling fullness to the brain.
Results could mark a "new era" in treating obesity with even more therapies on the horizon.
The most effective drug intervention we have seen for weight management.
In studies, a weekly injection caused dramatic amounts of weight loss and improved other heart-related risk factors.
2.4 mg of semaglutide once weekly plus lifestyle intervention was associated with sustained, clinically relevant reduction in body weight.
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These highly effective anti-obesity medications are associated with weight losses of more than 10% of overall bodyweight in more than two-thirds of clinical trial participants.
Results could mark a "new era" in treating obesity with even more therapies on the horizon.
The most effective drug intervention we have seen for weight management.
In studies, a weekly injection caused dramatic amounts of weight loss and improved other heart-related risk factors.
2.4 mg of semaglutide once weekly plus lifestyle intervention was associated with sustained, clinically relevant reduction in body weight.
These highly effective anti-obesity medications are associated with weight losses of more than 10% of overall bodyweight in more than two-thirds of clinical trial participants.
Results could mark a "new era" in treating obesity with even more therapies on the horizon.
The most effective drug intervention we have seen for weight management.
In studies, a weekly injection caused dramatic amounts of weight loss and improved other heart-related risk factors.
2.4 mg of semaglutide once weekly plus lifestyle intervention was associated with sustained, clinically relevant reduction in body weight.
These highly effective anti-obesity medications are associated with weight losses of more than 10% of overall bodyweight in more than two-thirds of clinical trial participants.
We believe in a sustainable and flexible approach to nutrition, without imposing limitations on your diet. Our goal is to guide you in establishing healthy eating habits, complemented by the medication's ability to decrease appetite and “food noise”. We encourage maintaining a nourishing, high-protein diet, but most patients are able to lose weight without the need for uncomfortably restrictive dieting or calorie counting.
Common side effects of tirzepatide are usually mild and may include:
• Nausea
• Vomiting
• Diarrhea
• Constipation
• Abdominal pain
• Decreased appetite
• Indigestion
The majority of side effects are transient and typically resolve spontaneously. Nevertheless, if side effects persist or deteriorate, seek guidance from a healthcare professional.
Willow also offers Odansetron to manage side effects if they occur. This medication is commonly used to prevent nausea and vomiting.
Tirzepatide Patient Safety Information
When stopping Tirzepatide abruptly, some patients may experience mild to moderate weight gain. Others may maintain the weight loss they achieved while on the medication. We recommend patients work with their Willow physician to slowly decrease their dose in order to maintain their weight loss achievements.
You may notice an increase in appetite and a return of food cravings, allowing you to eat more without feeling as full. However, stopping Tirzepatide is a safe and common practice that doesn't involve serious health risks. By gradually tapering off the medication with your physician’s guidance, you can better manage these changes and maintain your health and wellness goals.
Tirzepatide is administered once a week via a subcutaneous injection. Don’t worry! The needle is very small and short, making self-injection quick & easy. We’ll provide you with detailed written and video instructions that make the process simple and easy to follow. We even include a link to a soothing Spotify playlist to play in the background if you wish.
