Semaglutide vs. Tirzepatide
Understanding Your GLP-1 Options
Semaglutide
Signature weight loss
Starts at
$299/mo
$299/mo
HSA / FSA Eligible
Tirzepatide
Premium weight loss
Starts at
$399/mo
$399/mo
HSA / FSA Eligible
Compounded drug products are not approved or evaluated for safety, effectiveness, or quality by the FDA. Prescription products require an online consultation with a healthcare provider who will determine if a prescription is appropriate. Results may vary.
A note from Dr. Green
“Both Semaglutide and Tirzepatide are popular amongst Willow patients who have reported seeing weight loss. Tirzepatide tends to lead to greater weight loss for many patients, while Semaglutide remains a strong, reliable option. There's no single "better" choice between Semaglutide and Tirzepatide. What matters is what fits your body, your goals, and your lifestyle. Our doctors will walk you through the differences and help you land on the right option.”
Dr. Michael Green
MD, OB/GYN, Family Medicine
Semaglutide
Tirzepatide
Overview
GLP-1 receptor agonist
Mimics a natural hormone released after eating that helps regulate appetite, increase feelings of fullness, and support healthy blood sugar levels.
GLP-1 + GIP receptor agonist
Targets two metabolic hormone receptors (GLP-1 and GIP) that help regulate appetite, support fullness, and improve blood sugar control.
How do they work?
- Target hormones that regulate hunger and fullness
- Activate signals in the brain that control appetite
- Slow how quickly food leaves the stomach
- Help regulate how the body responds to food
- Work across key pathways involved in metabolism
- Help reduce food noise and cravings
Benefits
Reduces appetite and cravings
Helps you feel full sooner and stay full longer
Reduces appetite and cravings through dual-hormone signaling
Helps you feel full sooner and stay full longer
Pricing
Starting at
$299/month*
FSA & HSA eligible
Starting at
$399/month*
FSA & HSA eligible
*Pricing varies based on treatment plan and dosage. See full pricing details.
Included with plan
Medical evaluation and personalized treatment plan
GLP-1 medication tailored to you
Unlimited access to your Willow doctor
24/7 online support from your Willow Care Team
Free & discreet shipping
Semaglutide
Tirzepatide
Willow GLP-1s
Dosing
Semaglutide
Once-weekly injection
Gradual dose increase
Doctor-guided care
Needle-free option
Tirzepatide
Once-weekly injection
Gradual dose increase
Doctor-guided care
Needle-free option
Side Effects
Common side effects of Semaglutide and Tirzepatide are usually mild and temporary.
They may include:
They may include:
Nausea
Vomiting
Diarrhea
Vomiting
Diarrhea
Constipation
Abdominal pain
Decreased appetite
Abdominal pain
Decreased appetite
Indigestion
Redness at injection site
Redness at injection site
The majority of side effects are transient and typically resolve spontaneously. Nevertheless, if side effects persist or deteriorate, seek guidance from a healthcare professional.
Willow also offers Odansetron to manage side effects if they occur. This medication is commonly used to prevent nausea and vomiting.
Patient Safety Information
Willow also offers Odansetron to manage side effects if they occur. This medication is commonly used to prevent nausea and vomiting.
Patient Safety Information
Eligibility
Every patient’s metabolism, health history, and weight-loss goals are different. Your Willow doctor will review your medical history, medications, and treatment goals to determine whether treatment is appropriate.
If prescribed, your medication and dosing plan are personalized for you to ensure the treatment approach fits your individual needs.
If prescribed, your medication and dosing plan are personalized for you to ensure the treatment approach fits your individual needs.
What patients say
4.9/5 (2200 + 5 star reviews)
"I received a quick response from all involved. Since I am on maintenance and not starting from the beginning of my weight loss journey, I was surprised my inquiry was welcomed. Several other web sites did not want to even talk about my goals as they were only willing to prescribe for starting BMI and not look at maintaining that weight lost!"
Linda K.
"I was 100% satisfied with the experience, then Willow managed to improve the experience even more when a non-weight loss related issue came up suddenly. I could not have asked for better response time & actions taken. I'm so happy I chose Willow given all of the providers out there."
Susan K.
"Nothing but a good experience with Willow. I'm almost to my goal weight. I've lost 25 lbs. From the doctors to the staff everyone is great and very responsive. I've referred a friend and she is having a great experience too. Highly recommended!"
Olga C.
Compounded drug products are not approved or evaluated for safety, effectiveness, or quality by the FDA. Prescription products require an online consultation with a healthcare provider who will determine if a prescription is appropriate. Results may vary.
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