Semaglutide vs. Tirzepatide
Understanding Your GLP-1 Options
Semaglutide
Proven weight loss
Signature
Lose 15%
of body weight on average*
of body weight on average*
Starts at
$299/mo
$299/mo
HSA / FSA Eligible
Tirzepatide
Greater weight loss
Premium
Lose 20%
of body weight on average*
of body weight on average*
Starts at
$399/mo
$399/mo
HSA / FSA Eligible
*Average weight loss based on clinical study data in participants with overweight or obesity. Results for semaglutide are based on 68 weeks and tirzepatide on 72 weeks. Individual results may vary.
A note from Dr. Green
“Both Semaglutide and Tirzepatide are effective, clinically proven treatments for weight loss. Tirzepatide tends to lead to greater weight loss for many patients, while Semaglutide remains a strong, reliable option. The right choice depends on your goals, preferences, and budget. We’re here to help you find what fits best.”
Dr. Michael Green
MD, OB/GYN, Family Medicine
Semaglutide
Tirzepatide
Overview
GLP-1 receptor agonist
Mimics a natural hormone released after eating that helps regulate appetite, increase feelings of fullness, and support healthy blood sugar levels.
GLP-1 + GIP receptor agonist
Targets two metabolic hormone receptors (GLP-1 and GIP) that help regulate appetite, support fullness, and improve blood sugar control.
How do they work?
- Target hormones that regulate hunger and fullness
- Activate signals in the brain that control appetite
- Slow how quickly food leaves the stomach
- Help regulate how the body responds to food
- Work across key pathways involved in metabolism
- Help reduce food noise and cravings
Benefits
Reduces appetite and cravings
Helps you feel full sooner and stay full longer
Supports steady, clinically proven weight loss
Reduces appetite and cravings through dual-hormone signaling
Helps you feel full sooner and stay full longer
Greater average weight loss seen in clinical studies
Weight loss results
15% of body weight*
Average weight loss
20% of body weight*
Average weight loss
*Average weight loss based on clinical study data in participants with overweight or obesity. Results for semaglutide are based on 68 weeks and tirzepatide on 72 weeks. Individual results may vary.
Pricing
Starting at
$299/month*
FSA & HSA eligible
Starting at
$399/month*
FSA & HSA eligible
*Pricing varies based on treatment plan and dosage. See full pricing details.
Included with plan
Medical evaluation and personalized treatment plan
GLP-1 medication tailored to you
Unlimited access to your Willow doctor
24/7 online support from your Willow Care Team
Free & discreet shipping
Semaglutide
Tirzepatide
Willow GLP-1s
Dosing
Once-weekly injection
Gradual dose increase
Doctor-guided care
Needle-free option
Side Effects
Common side effects of Semaglutide and Tirzepatide are usually mild and temporary. They may include:
Nausea
Vomiting
Diarrhea
Vomiting
Diarrhea
Constipation
Abdominal pain
Decreased appetite
Abdominal pain
Decreased appetite
Indigestion
Redness at injection site
Redness at injection site
Most symptoms improve over time. Both medications start at a lower dose that gradually increases to help minimize discomfort. If symptoms persist or worsen, contact your healthcare professional.
Eligibility
Every patient’s metabolism, health history, and weight-loss goals are different. Your Willow doctor will review your medical history, medications, and treatment goals to determine whether treatment is appropriate.
If prescribed, your medication and dosing plan are personalized for you to ensure the treatment approach fits your individual needs.
If prescribed, your medication and dosing plan are personalized for you to ensure the treatment approach fits your individual needs.
What patients say
4.9/5 (2200 + 5 star reviews)
“Willow is hands down the best decision I’ve made for my health! The semaglutide injections have made it so much easier to lose weight. I don’t feel hungry all the time, and I don’t obsess over food anymore. I’ve lost 30 lbs, and I’m feeling more confident every day. Plus, their customer service is fantastic! 10/10 recommend!”
Ana O.
“I started Willow five months ago, and I’m already 35 lbs down! The tirzepatide injections are easy to administer (seriously, I was terrified at first, but it’s painless). My favorite thing about Willow is how supportive the doctors are. I’ve had a few questions about adjusting my dose, and they responded so quickly with helpful advice. It feels like I have a real team behind me!
Amanda R.
“I joined Willow after feeling stuck for years, and it’s been a breath of fresh air. The whole process was simple, and my provider made me feel understood from the start. They didn’t rush me or make me feel judged, just offered clear guidance that actually fit my life.”
Lena C.
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