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February 12, 2024
Weight Loss
February 12, 2024

Why Am I Not Losing Weight on Semaglutide?

On semaglutide but not seeing results yet? You’re not alone—and there may be valid reasons behind your experience. Let’s explore what might be happening and how you can optimize your results with the right strategies and support.

How Semaglutide Supports Weight Loss

Semaglutide is a GLP-1 receptor agonist that mimics a hormone naturally produced in the gut. It helps:

  • Increase insulin secretion
  • Reduce blood sugar levels
  • Slow stomach emptying
  • Decrease appetite and cravings

These effects combine to reduce overall calorie intake and support sustainable weight loss. But like any medication, semaglutide works differently for different people—and results take time.

Typical Weight Loss Timeline on Semaglutide

In clinical studies, participants taking semaglutide weekly lost:

  • ~5.9% of body weight after 3 months
  • ~10.9% after 6 months

However, individual results vary. Some people notice a difference in just a few weeks, while others need several months to see visible changes. The key? Patience, consistency, and personalized support.

10 Possible Reasons You’re Not Losing Weight on Semaglutide

1. You’re Not in a Caloric Deficit

Semaglutide reduces appetite, but if you’re still eating more calories than your body needs, weight loss may stall. Try tracking your intake for a few days to assess patterns and adjust portions or food choices as needed.

2. Your Dose Isn’t Therapeutic Yet

Semaglutide is typically started at a low dose and gradually increased over several weeks. Early doses are designed to minimize side effects—not necessarily promote weight loss. It may take time to reach a dose that produces more significant appetite suppression.

3. You’ve Hit a Plateau

Weight loss plateaus are common. Your metabolism adjusts, and your progress may temporarily slow. To move forward, consider:

  • Slightly reducing calorie intake
  • Adding resistance training
  • Changing your workout structure

4. Lifestyle Habits Haven’t Changed Enough

The medication is most effective when paired with nutritious eating habits, physical activity, and sleep hygiene. Take an honest look at your day-to-day choices and consider where you might need more structure or support.

5. Stress Is Sabotaging Progress

Chronic stress elevates cortisol, a hormone linked to weight gain and increased cravings. Prioritize:

  • Breathwork or meditation
  • Physical activity
  • Quality sleep
  • Supportive social connections

6. You’re Not Sleeping Enough

Lack of sleep disrupts appetite-regulating hormones like ghrelin and leptin. This can lead to:

  • Increased hunger
  • Decreased satiety
  • Lower energy for movement

Aim for 7–9 hours of restful sleep per night.

7. An Underlying Condition May Be Interfering

Certain medical conditions can make weight loss more difficult, including:

  • Hypothyroidism
  • PCOS
  • Insulin resistance

If you suspect a hormonal imbalance or metabolic issue, consult with your healthcare provider for testing and guidance.

8. Medication Use Has Been Inconsistent

Missing doses or not following administration instructions can impact results. Build a medication routine that fits your lifestyle—set alarms, use apps, or pair your dose with another daily habit.

9. Protein Intake Is Too Low

Protein helps with satiety and protects lean muscle during weight loss. Prioritize sources like:

  • Lean meats
  • Fish
  • Eggs
  • Legumes
  • Greek yogurt

A general target is 1.2 grams of protein per pound of your goal body weight.

10. You’re Lacking Support and Accountability

Weight loss is easier with support. Whether it’s a friend, coach, healthcare provider, or online community, having someone to check in with can boost consistency, motivation, and results.

How to Maximize Weight Loss on Semaglutide

✅ Talk to Your Provider

If you’re not seeing progress, start with a conversation. Your provider can:

  • Adjust your dosage
  • Run lab work for underlying conditions
  • Recommend a more personalized approach

✅ Track Your Intake and Habits

Use a journal or app to assess:

  • Calories and macronutrients
  • Sleep patterns
  • Stress levels
  • Exercise routines

This data can help identify opportunities for improvement.

✅ Reassess Your Fitness Routine

Movement matters. Aim for:

  • Cardio to burn calories
  • Strength training to preserve muscle
  • Stretching and mobility for recovery

Start with what you enjoy, then build gradually.

✅ Prioritize Hydration and Reduce Alcohol

Water supports digestion, satiety, and energy. Alcohol, on the other hand, contains empty calories and can increase cravings. Keep it minimal or skip it altogether.

✅ Be Patient and Stay Consistent

Weight loss isn’t always linear. Progress may come in waves. Focus on building habits you can maintain long term—and give your body time to respond.

Looking for Support?

If you’re feeling stuck or discouraged, Willow offers a comprehensive weight loss program featuring semaglutide, lifestyle guidance, and expert support to help you stay consistent and feel confident every step of the way.

Final Takeaway

Not losing weight on semaglutide doesn’t mean it’s not working—it may just mean your body needs more time, support, or adjustment. By addressing the most common obstacles and partnering with a healthcare professional, you can unlock the full potential of your journey.

Stay consistent. Stay curious. And most importantly—stay kind to yourself.

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