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Constipation affects approximately 9.5% of individuals taking semaglutide, according to clinical research. While not everyone experiences it, understanding why it happens can help you manage symptoms effectively.
Semaglutide works by slowing down the digestive process—including how quickly food moves through your stomach and intestines. This delayed gastric emptying can:
These changes are part of how the medication supports weight loss and appetite regulation, but they can also lead to temporary gastrointestinal discomfort.
Constipation related to semaglutide use typically improves over time. In one study, individuals reported a median duration of 47 days before symptoms resolved naturally. However, everyone’s response is different, and some may need additional support to manage discomfort.
1. Stay Hydrated
Drink plenty of fluids—aim for at least 8 cups (64 ounces) of water per day. Proper hydration keeps your stool softer and easier to pass.
2. Add More Fiber
Incorporate fiber-rich foods like:
Aim for 25–35 grams of fiber daily, and consider a fiber supplement if you struggle to meet that goal through food alone (check with your provider first).
3. Keep Moving
Physical activity can stimulate your digestive tract. Even light movement like brisk walking can help get things going. Aim for at least 60 minutes of moderate aerobic activity per week.
4. Establish a Bathroom Routine
Try to visit the bathroom at the same time every day, ideally after meals when digestion is active. Create a calm and unhurried environment to encourage regularity.
5. Consider Over-the-Counter Support
If diet and lifestyle changes aren’t enough, stool softeners or gentle laxatives may help—but only short-term. Avoid relying on them long-term, as they can lead to dependency. Always speak with your provider or pharmacist before adding these to your regimen.
6. Dosage Adjustments
If constipation is persistent, your provider may recommend adjusting your semaglutide dosage. Slowing down your titration schedule or temporarily reducing your dose can sometimes improve tolerance.
7. Seek Medical Advice
Don’t ignore ongoing digestive issues. If constipation becomes severe or lasts beyond a few weeks, contact your provider to explore additional treatment options or rule out other causes.
In addition to constipation, other gastrointestinal side effects may include:
Most of these are temporary and tend to improve as your body adjusts to the medication.
Conclusion
Constipation is a known but manageable side effect of semaglutide. By staying hydrated, increasing fiber, exercising regularly, and working closely with your healthcare provider, you can navigate this side effect while continuing to benefit from the medication’s weight loss and metabolic support.
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