Tretinoin Cream

Your skin’s night shift

A prescription tretinoin cream for adults dealing with fine lines and breakouts, often at the same time.

Tretinoin Cream

Your skin’s night shift

A prescription tretinoin cream for adults dealing with fine lines and breakouts, often at the same time.
$129/90-day supply
HSA / FSA Eligible

Smoother-looking skin and softer-looking fine lines

A clearer look you don’t have to plan around

Helps unclog pores while you sleep

Trusted by 100,000+ patients.
100% online care
Doctor-prescribed
Pharmacy-prepared
Same-day assessment
Free shipping
24/7 support
100% online care
Doctor-prescribed
Pharmacy-prepared
Same-day assessment
Free shipping
24/7 support
What is Tretinoin Cream?

Tretinoin Cream is a prescription cream for fine lines and breakouts. It’s prescription tretinoin, paired with niacinamide, sodium hyaluronate and aloe, chosen to complement it.

Tretinoin is a retinoid, a form of vitamin A, and the active ingredient. Niacinamide is a form of vitamin B3, sodium hyaluronate is a form of hyaluronic acid, which skin uses to hold onto water, and aloe is a plant extract that’s long been a skincare staple.

Tretinoin Cream is a compounded medication, and compounded medications aren’t FDA-approved.

Benefits

One cream for both

Fine lines and breakouts often show up at the same time. Tretinoin Cream is one prescription cream made for both.

A more even-looking tone

Tretinoin Cream is also made for more even-looking tone.

A simple nightly routine

A pea-sized amount at night, on dry skin, is all it takes. Pair it with SPF 30+ every day.

Individual results may vary.

May cause redness, peeling and sun sensitivity. Not for use during pregnancy or breastfeeding.

Who should use Tretinoin Cream?

Tretinoin Cream may be a good fit for adults dealing with fine lines, mild acne or both. It’s often a good option for people who:

  • have tried drugstore creams without the results they want
  • want a doctor’s plan without a separate dermatology visit
  • want skin they don’t have to think about

‍

Tretinoin Cream is not appropriate for everyone. You should not use it if you are pregnant, trying to conceive or breastfeeding, have eczema or another chronic facial skin condition other than acne, or use another tretinoin or retinoid product. If you take isotretinoin, your doctor will review it first. If you already use tretinoin, tell your doctor. You’ll stay at your current strength.

Tretinoin Cream may be prescribed to eligible adults 18 and older. A Willow doctor will review your health history and determine if treatment is right for you.

Can I use Tretinoin Cream with other treatments?

Possibly, and your doctor will check. During your online assessment, you’ll share your health history and any medications or supplements you take. Your Willow doctor reviews them for possible interactions before prescribing, and you can message them if anything changes after you start.

How do I use Tretinoin Cream?

Apply a pea-sized amount (about 1/4 to 1/2 pump) to fully dry skin at night. Use it every other night for the first 2 weeks, then nightly, and wear SPF 30+ every day, since tretinoin makes your skin more sensitive to the sun. If your skin gets irritated, message your Willow doctor, who may have you use it less often.

The Willow difference

US-licensed doctors
Transparent pricing, no hidden fees
Needle-free options
24/7 human support
Zero judgment
Others
Nurse practitioners or physician assistants
Add-on fees for visits or follow-ups
Injectable only
AI-powered support
Comes with a lecture

Breakouts missed the memo

Now fine lines are showing up alongside them,
even on a good skin day.

The science behind Tretinoin Cream

Tretinoin, the active ingredient in Tretinoin Cream, is a retinoid, a form of vitamin A. It speeds up how fast skin cells turn over and loosens the cells that clog pores.

Starting slow gives your skin time to adjust, which is why you use it every other night for the first 2 weeks. Dryness or purging in weeks 2 to 6 is expected, and combining it with other products may cause  irritation, not faster results.

Changes in how your skin looks take time, and results vary from person to person.

What to expect from Tretinoin Cream

Patients may notice:

Skin that looks smoother and more even

Fine lines that appear softer

Clearer-looking skin they don’t have to plan around

Skipping the makeup and not thinking twice about it

Getting started with Willow

Three simple steps to get started

1
Assessment
and review
FSA & HSA eligible
Answer a few questions about your health and goals. A US-licensed physician reviews your assessment, usually within 24 hours. If treatment is right for you, they'll confirm your prescription.
FSA & HSA eligible
2
Preparation
and shipping
Your prescription is prepared by trusted US pharmacy partners. It ships with tracking, so you always know where it is.
FSA & HSA eligible
3
Delivery
and support
Your treatment arrives in discreet packaging. From there, you'll have unlimited doctor messaging and 24/7 Care Team support.
FSA & HSA eligible

Getting started with Willow

Three simple steps to weight loss care
1
Assessment and review
Answer a few questions about your health and goals. A US-licensed physician reviews your assessment, usually within 24 hours. If treatment is right for you, they'll confirm your prescription.
FSA & HSA eligible
2
Preparation and shipping
Your prescription is prepared by trusted US pharmacy partners. It ships with tracking, so you always know where it is.
FSA & HSA eligible
3
Delivery and support
Your treatment arrives in discreet packaging. From there, you'll have unlimited doctor messaging and 24/7 Care Team support.
FSA & HSA eligible

A note from Dr. Green

As Willow’s Chief Medical Officer, I look closely at how treatments hold up in real life, beyond how they perform on paper.

If you want to look and feel your best, there’s no single way to get there. When a plan fits your body and your life, it can help you feel more confident and comfortable in your own skin. 

That’s why we build your treatment plan around you. You shouldn’t have to adjust to your care. Your care should adjust to you.
Individual results may vary.

Prescription treatment

Medication chosen around your health history and goals, with a treatment plan built for you.

Guided by doctors

Every Willow prescriber is a U.S. licensed physician who oversees your treatment and adjusts it as needed.

Judgement-free care

No office visits. 100% online. Access to your doctor and the Willow Patient Care Services Team whenever you need it.

What patients say about Willow

4.9/5 (2200 + 5 star reviews)
"I was 100% satisfied with the experience, then Willow managed to improve the experience even more when a non-weight loss related issue came up suddenly. I could not have asked for better response time & actions taken. I'm so happy I chose Willow given all of the providers out there."
Susan K.
"Nothing but a good experience with Willow. I'm almost to my goal weight. I've lost 25 lbs. From the doctors to the staff everyone is great and very responsive. I've referred a friend and she is having a great experience too. Highly recommended!"
Olga C.
"I’m super happy with using Willow so far. The medication really works well, their doctors are always responsive and ready to help. Their customer service email seems to be working 24/7 and they are always super helpful and flexible."
Natalja M.
"Love everything about my experience with Willow. I felt my issues were taken seriously and addressed quickly and with respect. The level of communication means I know any issues or concerns will be taken care of in a short amount of time. Not to mention the relief of my menopause symptoms with the prescriptions given to me."
Lisa G.
"Great and seamless experience, highly dependable delivery and product. And always available staff for any consultation or advice."
Anka

Tretinoin Cream FAQs

What’s included?

Your Tretinoin Cream includes one 30mL pump bottle, a 90-day supply. Your medication is prepared by the pharmacy and shipped to you in discreet packaging, with shipping included. You’ll also have support from your Willow doctor and the Care Team.

When will I notice results?

Experiences and timelines vary from patient to patient, and no specific result can be promised. Tretinoin has an adjustment period, so the first weeks are about getting used to it. If you have questions about how your skin is responding, message your Willow doctor.

How should I store Tretinoin Cream?

Store Tretinoin Cream at room temperature, between 68°F and 77°F. Use it by the date on the label.

Can I change or cancel my treatment plan?

Yes. Your Willow doctor can adjust your treatment as your needs change, and you can cancel anytime. Message your doctor to discuss your options.

Is Tretinoin HSA/FSA eligible?

In most cases, yes. Willow accepts HSA and FSA cards at checkout. Whether a specific purchase is eligible depends on your plan and applicable IRS rules, so check with your plan administrator.

Are there any side effects?

Like any prescription treatment, Tretinoin Cream can cause side effects. Common side effects are redness, peeling, dryness, burning and a temporary flare of breakouts, especially in the first weeks. Stop using it and contact your doctor if you have severe redness, swelling, blistering or crusting, eye irritation or signs of an allergic reaction. Full details can be found in our Patient Safety Information.

When you feel better, it shows

In the way you see yourself, and the confidence you carry with you.