Tretinoin Cream
A prescription tretinoin cream for adults dealing with fine lines and breakouts, often at the same time.





Tretinoin Cream
A prescription tretinoin cream for adults dealing with fine lines and breakouts, often at the same time.
Smoother-looking skin and softer-looking fine lines
A clearer look you don’t have to plan around
Helps unclog pores while you sleep
Tretinoin Cream is a prescription cream for fine lines and breakouts. It’s prescription tretinoin, paired with niacinamide, sodium hyaluronate and aloe, chosen to complement it.
Tretinoin is a retinoid, a form of vitamin A, and the active ingredient. Niacinamide is a form of vitamin B3, sodium hyaluronate is a form of hyaluronic acid, which skin uses to hold onto water, and aloe is a plant extract that’s long been a skincare staple.
Tretinoin Cream is a compounded medication, and compounded medications aren’t FDA-approved.
One cream for both
Fine lines and breakouts often show up at the same time. Tretinoin Cream is one prescription cream made for both.
A more even-looking tone
Tretinoin Cream is also made for more even-looking tone.
A simple nightly routine
A pea-sized amount at night, on dry skin, is all it takes. Pair it with SPF 30+ every day.
Individual results may vary.
May cause redness, peeling and sun sensitivity. Not for use during pregnancy or breastfeeding.
Tretinoin Cream may be a good fit for adults dealing with fine lines, mild acne or both. It’s often a good option for people who:
- have tried drugstore creams without the results they want
- want a doctor’s plan without a separate dermatology visit
- want skin they don’t have to think about
Tretinoin Cream is not appropriate for everyone. You should not use it if you are pregnant, trying to conceive or breastfeeding, have eczema or another chronic facial skin condition other than acne, or use another tretinoin or retinoid product. If you take isotretinoin, your doctor will review it first. If you already use tretinoin, tell your doctor. You’ll stay at your current strength.
Tretinoin Cream may be prescribed to eligible adults 18 and older. A Willow doctor will review your health history and determine if treatment is right for you.
Possibly, and your doctor will check. During your online assessment, you’ll share your health history and any medications or supplements you take. Your Willow doctor reviews them for possible interactions before prescribing, and you can message them if anything changes after you start.
Apply a pea-sized amount (about 1/4 to 1/2 pump) to fully dry skin at night. Use it every other night for the first 2 weeks, then nightly, and wear SPF 30+ every day, since tretinoin makes your skin more sensitive to the sun. If your skin gets irritated, message your Willow doctor, who may have you use it less often.

The Willow difference
The science behind Tretinoin Cream
Starting slow gives your skin time to adjust, which is why you use it every other night for the first 2 weeks. Dryness or purging in weeks 2 to 6 is expected, and combining it with other products may cause irritation, not faster results.
Changes in how your skin looks take time, and results vary from person to person.
What to expect from Tretinoin Cream
Skin that looks smoother and more even
Fine lines that appear softer
Clearer-looking skin they don’t have to plan around
Skipping the makeup and not thinking twice about it
A note from Dr. Green
If you want to look and feel your best, there’s no single way to get there. When a plan fits your body and your life, it can help you feel more confident and comfortable in your own skin.
That’s why we build your treatment plan around you. You shouldn’t have to adjust to your care. Your care should adjust to you.
What patients say about Willow
Tretinoin Cream FAQs
Your Tretinoin Cream includes one 30mL pump bottle, a 90-day supply. Your medication is prepared by the pharmacy and shipped to you in discreet packaging, with shipping included. You’ll also have support from your Willow doctor and the Care Team.
Experiences and timelines vary from patient to patient, and no specific result can be promised. Tretinoin has an adjustment period, so the first weeks are about getting used to it. If you have questions about how your skin is responding, message your Willow doctor.
Store Tretinoin Cream at room temperature, between 68°F and 77°F. Use it by the date on the label.
Yes. Your Willow doctor can adjust your treatment as your needs change, and you can cancel anytime. Message your doctor to discuss your options.
In most cases, yes. Willow accepts HSA and FSA cards at checkout. Whether a specific purchase is eligible depends on your plan and applicable IRS rules, so check with your plan administrator.
Like any prescription treatment, Tretinoin Cream can cause side effects. Common side effects are redness, peeling, dryness, burning and a temporary flare of breakouts, especially in the first weeks. Stop using it and contact your doctor if you have severe redness, swelling, blistering or crusting, eye irritation or signs of an allergic reaction. Full details can be found in our Patient Safety Information.
















