Estriol Skin Cream
Support your changing skin with a prescription face and neck cream containing 0.3% estriol.
Estriol Skin Cream
Support your changing skin with a prescription face and neck cream containing 0.3% estriol.
Firmer, smoother-looking skin on your face and neck
A more hydrated look, without adding more steps
Foundation that goes on a little smoother
Estriol Skin Cream is a prescription face cream for skin that’s changing through perimenopause and menopause. It’s made with 0.3% estriol and supports firmer-, smoother-looking skin that looks more hydrated.
Estriol is a form of estrogen. Estriol Skin Cream is applied to your face and neck for the look of your skin, and it’s not menopause hormone therapy. At 0.3%, it acts in your skin and doesn’t meaningfully raise blood levels.
Estriol Skin Cream is a compounded medication, and compounded medications aren’t FDA-approved. There’s no FDA-approved estriol product in the U.S.
Firmer, smoother-looking skin
At 0.3%, estriol acts in your skin to support firmer-, smoother-looking skin on your face and neck.
A more hydrated look
Estriol Skin Cream helps skin look more hydrated, without adding more steps to your routine.
A once-a-day routine
One pea-sized amount on your face and neck, once a day, at any time that suits you.
Individual results may vary.
Compounded; not FDA-approved. Contains estrogen. May cause skin redness or irritation. Not for use during pregnancy or breastfeeding.
Estriol Skin Cream may be a good fit for women in perimenopause or after menopause who want firmer-, smoother-looking skin that looks more hydrated. It’s often a good option for people who:
- feel their skin is thinner, drier or less firm than it was a few years ago
- find that their moisturizer isn’t keeping up
- want a doctor’s take before they try a cream like this
Estriol Skin Cream is not appropriate for everyone. You should not use it if you are pregnant, trying to conceive or breastfeeding, or are allergic to estriol or any ingredient. Your doctor also reviews eczema, rosacea, dermatitis or melasma on your face, and any recent peel, laser treatment or facial waxing. If you’re on hormone therapy, tell your doctor.
Estriol Skin Cream may be prescribed to eligible women 18 and older. A Willow doctor will review your health history and your skin and determine if treatment is right for you.
Possibly, and your doctor will check. During your online assessment, you’ll share your health history and any medications or supplements you take. Your Willow doctor reviews them for possible interactions before prescribing, and you can message them if anything changes after you start.
Estriol Skin Cream can also sit beside Tretinoin Cream and GHK-Cu 3% Cream in one personalized skin protocol, if your doctor prescribes them.
Apply a pea-sized amount (about 0.5g) to clean, dry skin on your face and neck once a day, at any time that suits you. Keep it away from your eyes and lips, wash your hands after you apply it and wear sunscreen every day. Using more won’t speed up results.
The Willow difference
The science behind Estriol Skin Cream
At 0.3% on your face and neck, estriol works right where you put it, in your skin, and doesn’t meaningfully raise blood levels. That’s why it’s skincare, not hormone therapy.
Skin changes through perimenopause and menopause are part of life, and wanting great skin at every stage is reason enough to ask for support.
What to expect from Estriol Skin Cream
Feeling at home in their skin again
A routine that fits the skin they have now
Getting ready with one less thing to worry about
Feeling ready to head out, mirror check or not
A note from Dr. Green
If you want to look and feel your best, there’s no single way to get there. When a plan fits your body and your life, it can help you feel more confident and comfortable in your own skin.
That’s why we build your treatment plan around you. You shouldn’t have to adjust to your care. Your care should adjust to you.
Prescription treatment
Guided by doctors
Judgement-free care
What patients say about Willow
Estriol Skin Cream FAQs
Your Estriol Skin Cream includes one 50mL pump bottle, a 90-day supply. It is prepared by the pharmacy and shipped to you in discreet packaging, with shipping included. You’ll also have support from your Willow doctor and the Care Team.
Experiences and timelines vary from patient to patient, and no specific result can be promised. Estriol Skin Cream is a once-a-day routine, and changes take time with daily use. If you have questions about how your skin is responding, message your Willow doctor.
Store Estriol Skin Cream at room temperature, between 68°F and 77°F. Use it by the date on the label.
Yes. Your Willow doctor can adjust your treatment as your needs change, and you can cancel anytime. Message your doctor to discuss your options.
Like any prescription treatment, Estriol Skin Cream can cause side effects. These may include redness, irritation or dryness where applied. Stop using it and contact your doctor if you have a rash, persistent redness, burning, swelling or dark patches on your skin. Full details can be found in our Patient Safety Information.
