Daily Calming Cream

A gentle, daily ritual for everyday stress

A compounded oxytocin cream for the stress that builds between the inbox, the commute and everything else.

Daily Calming Cream

A gentle, daily ritual for everyday stress

A compounded oxytocin cream for the stress that builds between the inbox, the commute and everything else.
$129/mo
HSA / FSA Eligible

A calmer baseline for busy days

A gentle, daily ritual that takes 10 seconds

Made with a hormone your body already produces

Trusted by 100,000+ patients.
100% online care
Doctor-prescribed
Pharmacy-prepared
Same-day assessment
Free shipping
24/7 support
100% online care
Doctor-prescribed
Pharmacy-prepared
Same-day assessment
Free shipping
24/7 support
What is Daily Calming Cream?

Daily Calming Cream is a doctor-prescribed, compounded oxytocin cream for everyday stress. You use 1 pump on your inner wrist or forearm, once a day.

It contains oxytocin, a naturally occurring hormone, in a cream base made to help it absorb through thin skin, like your inner wrist.

Daily Calming Cream is a compounded medication, and compounded medications aren’t FDA-approved. It isn’t FDA-approved for stress or anxiety.

Benefits

Made for the everyday

Daily Calming Cream is made for day-to-day stress, tension and calm. It’s a gentle ritual you do every day, not something you reach for on a bad day.

A familiar hormone

Oxytocin is a naturally occurring hormone, linked to dampening the stress response. Daily Calming Cream puts it in a gentle, daily ritual for everyday stress.

Subtle by design

The effects are subtle, more of a steady background than an on switch, so set it up as a steady daily ritual.

Individual results may vary.

It is a compounded medication, and is not FDA-approved. May cause skin irritation or headache. Not for use during pregnancy, while trying to conceive, or while breastfeeding.

Who should use Daily Calming Cream?

Daily Calming Cream may be a good fit for adults 18 and older who want support with everyday stress. It’s often a good option for people who:

  • deal with the everyday kind of stress, like a busy workday or a full to-do list
  • are curious about prescription support for stress
  • want a simple, once-a-day routine

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Daily Calming Cream isn’t a treatment for severe anxiety, panic disorder or depression. If you need more support, talk to your Willow doctor. If you’re having thoughts of harming yourself, call or text 988.

Daily Calming Cream is not appropriate for everyone. You should not use it if you are pregnant, trying to conceive or breastfeeding, or are allergic to oxytocin. Your doctor also reviews any history of low sodium, fluid retention, an irregular heartbeat or long QT.

Daily Calming Cream may be prescribed to eligible adults 18 and older. A Willow doctor will review your health history and determine if treatment is right for you.

Can I use Daily Calming Cream with other treatments?

Possibly, and your doctor will check. During your online assessment, you’ll share your health history and any medications or supplements you take. Your Willow doctor reviews them for possible interactions before prescribing, and you can message them if anything changes after you start.

How do I use Daily Calming Cream?

Press the pump once onto clean, dry skin on your inner wrist or inner forearm and rub it in until it’s absorbed. Wash your hands right away and avoid skin contact with anyone who is pregnant until the cream has absorbed. Use 1 pump, once a day, since more won’t make it work better.

The Willow difference

US-licensed doctors
Transparent pricing, no hidden fees
Needle-free options
24/7 human support
Zero judgment
Others
Nurse practitioners or physician assistants
Add-on fees for visits or follow-ups
Injectable only
AI-powered support
Comes with a lecture

Not a crisis, just a lot of Tuesdays

It’s not big enough to feel like a crisis, but the small stresses add up and follow you home.

The science behind Daily Calming Cream

Oxytocin, the active ingredient in Daily Calming Cream, is a naturally occurring hormone that acts on oxytocin receptors throughout the brain and body. It’s linked to dampening the stress response.

Daily Calming Cream puts oxytocin in a cream base made to help it absorb through thin skin, which is why it goes on your inner wrist or forearm. The effects are subtle, more of a steady background than an on switch, which is why you use it once a day.

Everyday stress is reason enough to ask for support. Your body already makes oxytocin, the same hormone it releases during a hug, holding hands or time with your pet. A Willow doctor can prescribe it if it’s right for you.

What to expect from Daily Calming Cream

Patients may notice:

A calmer body, day to day

Small stresses that stay small

Busy days that feel a little lighter

Feeling more like themselves after a long day

Getting started with Willow

Three simple steps to get started

1
Assessment
and review
FSA & HSA eligible
Answer a few questions about your health and goals. A US-licensed physician reviews your assessment, usually within 24 hours. If treatment is right for you, they'll confirm your prescription.
FSA & HSA eligible
2
Preparation
and shipping
Your prescription is prepared by trusted US pharmacy partners. It ships with tracking, so you always know where it is.
FSA & HSA eligible
3
Delivery
and support
Your treatment arrives in discreet packaging. From there, you'll have unlimited doctor messaging and 24/7 Care Team support.
FSA & HSA eligible

Getting started with Willow

Three simple steps to weight loss care
1
Assessment and review
Answer a few questions about your health and goals. A US-licensed physician reviews your assessment, usually within 24 hours. If treatment is right for you, they'll confirm your prescription.
FSA & HSA eligible
2
Preparation and shipping
Your prescription is prepared by trusted US pharmacy partners. It ships with tracking, so you always know where it is.
FSA & HSA eligible
3
Delivery and support
Your treatment arrives in discreet packaging. From there, you'll have unlimited doctor messaging and 24/7 Care Team support.
FSA & HSA eligible

A note from Dr. Green

As Willow’s Chief Medical Officer, I look closely at how treatments hold up in real life, beyond how they perform on paper.

If you want to look and feel your best, there’s no single way to get there. When a plan fits your body and your life, it can help you feel more confident and comfortable in your own skin. 

That’s why we build your treatment plan around you. You shouldn’t have to adjust to your care. Your care should adjust to you.
Individual results may vary.

Prescription treatment

Medication chosen around your health history and goals, with a treatment plan built for you.

Guided by doctors

Every Willow prescriber is a U.S. licensed physician who oversees your treatment and adjusts it as needed.

Judgement-free care

No office visits. 100% online. Access to your doctor and the Willow Patient Care Services Team whenever you need it.

What patients say about Willow

4.9/5 (2200 + 5 star reviews)
"I was 100% satisfied with the experience, then Willow managed to improve the experience even more when a non-weight loss related issue came up suddenly. I could not have asked for better response time & actions taken. I'm so happy I chose Willow given all of the providers out there."
Susan K.
"Nothing but a good experience with Willow. I'm almost to my goal weight. I've lost 25 lbs. From the doctors to the staff everyone is great and very responsive. I've referred a friend and she is having a great experience too. Highly recommended!"
Olga C.
"I’m super happy with using Willow so far. The medication really works well, their doctors are always responsive and ready to help. Their customer service email seems to be working 24/7 and they are always super helpful and flexible."
Natalja M.
"Love everything about my experience with Willow. I felt my issues were taken seriously and addressed quickly and with respect. The level of communication means I know any issues or concerns will be taken care of in a short amount of time. Not to mention the relief of my menopause symptoms with the prescriptions given to me."
Lisa G.
"Great and seamless experience, highly dependable delivery and product. And always available staff for any consultation or advice."
Anka

Daily Calming Cream FAQs

What’s included?

Your Daily Calming Cream comes in a pump bottle, and can be prescribed in a 30-day or 90-day size. It is prepared by the pharmacy and shipped to you in discreet packaging, with shipping included. You’ll also have support from your Willow doctor and the Care Team.

When will I notice results?

Experiences and timelines vary from patient to patient, and no specific result can be promised. The effects are subtle, so use it as a steady daily ritual. If you have questions about how it’s working for you, message your Willow doctor.

How should I store Daily Calming Cream?

Store Daily Calming Cream at room temperature, between 68°F and 77°F. In warmer months, it may arrive packed with ice. Use it by the date on the label.

Can I change or cancel my treatment plan?

Yes. Your Willow doctor can adjust your treatment as your needs change, and you can cancel anytime. Message your doctor to discuss your options.

Is Daily Calming Cream HSA/FSA eligible?

In most cases, yes. Willow accepts HSA and FSA cards at checkout. Whether a specific purchase is eligible depends on your plan and applicable IRS rules, so check with your plan administrator.

Are there any side effects?

Like any prescription treatment, Daily Calming Cream can cause side effects. These may include headache or skin irritation where applied. Stop using it and contact your doctor if you have a rash, cramping, unusual bleeding or a racing or irregular heartbeat. Full details can be found in our Patient Safety Information.

When you feel better, it shows

In the way you see yourself, and the confidence you carry with you.