Daily Calming Cream
A compounded oxytocin cream for the stress that builds between the inbox, the commute and everything else.





Daily Calming Cream
A compounded oxytocin cream for the stress that builds between the inbox, the commute and everything else.
A calmer baseline for busy days
A gentle, daily ritual that takes 10 seconds
Made with a hormone your body already produces
Daily Calming Cream is a doctor-prescribed, compounded oxytocin cream for everyday stress. You use 1 pump on your inner wrist or forearm, once a day.
It contains oxytocin, a naturally occurring hormone, in a cream base made to help it absorb through thin skin, like your inner wrist.
Daily Calming Cream is a compounded medication, and compounded medications aren’t FDA-approved. It isn’t FDA-approved for stress or anxiety.
Made for the everyday
Daily Calming Cream is made for day-to-day stress, tension and calm. It’s a gentle ritual you do every day, not something you reach for on a bad day.
A familiar hormone
Oxytocin is a naturally occurring hormone, linked to dampening the stress response. Daily Calming Cream puts it in a gentle, daily ritual for everyday stress.
Subtle by design
The effects are subtle, more of a steady background than an on switch, so set it up as a steady daily ritual.
Individual results may vary.
It is a compounded medication, and is not FDA-approved. May cause skin irritation or headache. Not for use during pregnancy, while trying to conceive, or while breastfeeding.
Daily Calming Cream may be a good fit for adults 18 and older who want support with everyday stress. It’s often a good option for people who:
- deal with the everyday kind of stress, like a busy workday or a full to-do list
- are curious about prescription support for stress
- want a simple, once-a-day routine
Daily Calming Cream isn’t a treatment for severe anxiety, panic disorder or depression. If you need more support, talk to your Willow doctor. If you’re having thoughts of harming yourself, call or text 988.
Daily Calming Cream is not appropriate for everyone. You should not use it if you are pregnant, trying to conceive or breastfeeding, or are allergic to oxytocin. Your doctor also reviews any history of low sodium, fluid retention, an irregular heartbeat or long QT.
Daily Calming Cream may be prescribed to eligible adults 18 and older. A Willow doctor will review your health history and determine if treatment is right for you.
Possibly, and your doctor will check. During your online assessment, you’ll share your health history and any medications or supplements you take. Your Willow doctor reviews them for possible interactions before prescribing, and you can message them if anything changes after you start.
Press the pump once onto clean, dry skin on your inner wrist or inner forearm and rub it in until it’s absorbed. Wash your hands right away and avoid skin contact with anyone who is pregnant until the cream has absorbed. Use 1 pump, once a day, since more won’t make it work better.

The Willow difference
The science behind Daily Calming Cream
Daily Calming Cream puts oxytocin in a cream base made to help it absorb through thin skin, which is why it goes on your inner wrist or forearm. The effects are subtle, more of a steady background than an on switch, which is why you use it once a day.
Everyday stress is reason enough to ask for support. Your body already makes oxytocin, the same hormone it releases during a hug, holding hands or time with your pet. A Willow doctor can prescribe it if it’s right for you.
What to expect from Daily Calming Cream
A calmer body, day to day
Small stresses that stay small
Busy days that feel a little lighter
Feeling more like themselves after a long day
A note from Dr. Green
If you want to look and feel your best, there’s no single way to get there. When a plan fits your body and your life, it can help you feel more confident and comfortable in your own skin.
That’s why we build your treatment plan around you. You shouldn’t have to adjust to your care. Your care should adjust to you.
What patients say about Willow
Daily Calming Cream FAQs
Your Daily Calming Cream comes in a pump bottle, and can be prescribed in a 30-day or 90-day size. It is prepared by the pharmacy and shipped to you in discreet packaging, with shipping included. You’ll also have support from your Willow doctor and the Care Team.
Experiences and timelines vary from patient to patient, and no specific result can be promised. The effects are subtle, so use it as a steady daily ritual. If you have questions about how it’s working for you, message your Willow doctor.
Store Daily Calming Cream at room temperature, between 68°F and 77°F. In warmer months, it may arrive packed with ice. Use it by the date on the label.
Yes. Your Willow doctor can adjust your treatment as your needs change, and you can cancel anytime. Message your doctor to discuss your options.
In most cases, yes. Willow accepts HSA and FSA cards at checkout. Whether a specific purchase is eligible depends on your plan and applicable IRS rules, so check with your plan administrator.
Like any prescription treatment, Daily Calming Cream can cause side effects. These may include headache or skin irritation where applied. Stop using it and contact your doctor if you have a rash, cramping, unusual bleeding or a racing or irregular heartbeat. Full details can be found in our Patient Safety Information.
















